Impact of Obesity on a Chinese Population with Erosive Esophagitis and Barrett’s Esophagus
نویسندگان
چکیده
Background/Aims The aim of this study was to investigate the associations between obesity and erosive esophagitis (EE) or Barrett's esophagus (BE) in a Chinese population. Methods Data from subjects were retrospectively collected from 2006 to 2009. Individuals with BE were identified and age- and sex-matched at a 1:2 ratio with normal esophagocardial junction and EE patients. The subjects were stratified into two groups: the normal weight group and overweight/ obesity group (body mass index ≥25 mg/m²) or the normal waist group and abdominal obesity group (waist circumference ≥90 cm for men and ≥80 cm for women). Results Overall, 45%, 72%, and 52% were overweight/obese and 23%, 65%, and 18% had abdominal obesity in the normal, EE, and BE groups, respectively. Positive associations were identified between EE and overweight/obesity (odds ratio [OR], 3.14; 95% confidence interval [CI], 1.75 to 5.66) and abdominal obesity (OR, 6.22; 95% CI, 3.34 to 11.57); however, the associations were nonsignificant between BE and overweight/obesity (OR, 1.32; 95% CI, 0.67 to 2.61) or abdominal obesity (OR, 0.73; 95% CI, 0.31 to 1.73). Female BE patients had a significantly increased rate of being overweight/obese. Conclusions Obesity is a contributing factor in EE. The association of BE and obesity was not significant, with the exception of female BE cases.
منابع مشابه
Barrett’s Esophagus - American Family Physician
managed in the primary care setting. Surveys suggest that approximately 20 percent of U.S. adults have symptoms of GERD at least once a week.4 A subgroup of patients with GERD develop severe complications that include erosive esophagitis, stricture formation, Barrett’s esophagus, and adenocarcinoma of the esophagus. Because Barrett’s esophagus is thought to be associated with the development of...
متن کاملSilent gastroesophageal disease: clinical implications of an unknown disease.
Gastroesophageal reflux disease (GERD) is usually associated with the classical symptoms of heartburn and acid regurgitation, which have, in clinical practice, defined the disease. However it has long been known that extra-esophageal GERD and Barrett’s esophagus occur in patients without typical reflux symptoms. In recent years, several studies have uncovered a significant proportion of patient...
متن کاملAuthor's response to reviews Title: Alcohol consumption is associated with an increased risk of erosive esophagitis and Barrett's epithelium in Japanese men Authors:
background “the roles~are less well defined~” The authors must explain what the roles are less well defined than or in another way amend this sentence which is currently incomplete. As you pointed out, this sentence needs to be amended. The Background section of the Abstract was revised as follows: Evidence regarding the association between alcohol consumption and the gastro-esophageal reflux d...
متن کاملLow-Grade Dysplasia in Patients with Barrett’s Esophagus — Ablate?
A 73-year-old, obese white male with a history of hypertension and obstructive sleep apnea noted new onset nocturnal heartburn for six weeks. He was prescribed Ranitidine 150 mg orally at night by his primary care doctor, which initially controlled his symptoms. Three months later he noted substernal “burning” after eating spicy or high fat foods and returned to his primary care physician. Cons...
متن کاملMetformin With Either Histamine H2-Receptor Antagonists or Proton Pump Inhibitors: A Polypharmacy Recipe for Neuropathy via Vitamin B12 Depletion
According to the most recent data from the Centers for Disease Control and Prevention, 25.8 million people in the United States (8.3% of the population) have diabetes (1). Type 2 diabetes accounts for 90–95% of diabetes diagnoses, and >85% of people with type 2 diabetes are overweight or obese (1). Increased BMI, which is common in the type 2 diabetes population, has a well-established associat...
متن کامل